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主要科研成果（近年）：
一、发表文章
- XinyuFang,JinfengZhao,Simin Wu,PengLiao,Guiping Guan*.The intestinal toxicity mechanisms of triclosan and triclocarban and their possible clinical nutritional intervention mechanisms.Environmental Pollution, 2025,376:126396.
- XinyuFang,JinfengZhao,Simin Wu,PengLiao,Guiping Guan*. Investigating the mechanisms of Triclocarban-induced liver injury: A comprehensive analysisbased on network toxicology and in vivo experiments.Environmental Pollution, 2025, 384: 126953.
- Hu Xiangdong,Han Xuebing,Liu Gang,Guan Guiping,Xia Chenmei. Ferulic acid and N-Feruloylserotonin ameliorate LPS-induced intestinal inflammation via modulation of gut microbiota, metabolome, and transcriptome.Front Microbiol. 2025,16:1597774
- Jiang Wan-Jun,Mao Xin-Tao, Li Wen-Ping, Jin Nicole, Wang Yu,Guiping Guan*,Jin Jin, Li Yi-Yuan. NAT10-mediated acetylation of NIK mRNA in B cells promotes IgA production. EMBO Rep. 2025, 26(15):3917-3936.
- ZhangW., Zhu L., Wang H.,Zou Z.,Jiang Y.,Zhou Q., Xu Y.,Jiang W.,Guiping Guan*.Int J Environ Sci Technol., 2025, 22(10): 9767-9780.
- He Yuedong, Zhang Jing, HeYuewei, Tian Yun, Liu Huhu, Wang Chong,Guan Guiping,et al.. Integrated metabolome and transcriptome analyses revealed key cytochrome P450 genes involved in the biosynthesis of oleanane-type saponins inHederahelixL. 2025,223:109818.
- Guo Yiting,He Fang, Deng Zhiying,Yin Jie,Guiping Guan,*Xie Zhengjun, Zhou Xihong. Dietary Serine Supplementation Improves Growth Performance, Intramuscular Fat Content, and Composition of Gut Microbes and Metabolites in Growing-Finishing Pigs. AGRICULTURE-BASEL, 2024, 14(3): 14030349.
- R. Zhao, Q. Zhang, T. Huang, Y. Tian,G. Guan,Y. Lin. Effect of the combination of clostridium butyricum and mycelium of Phellinus igniarius on intestinal microbiota and serum metabolites in DSS-induced colitis.Nutrients,2024 , 16(1):16010153.
- Fu Yifeng, Wang Qiangfeng, Tang Zihan,Liu Gang,Guan Guiping,Lyu Jin.Cordycepin Ameliorates High Fat Diet-Induced Obesity by Modulating Endogenous Metabolism and Gut Microbiota Dysbiosis. Nutrients,2024, 16(17 ):16172859.
- Xihong Zhou, Yiwen He, Jingqing Chen, Xia Xiong, Jie Yin, Jing Liang, Can Peng, Chunxia Huang,Guiping Guan,Yulong Yin. Colonic phosphocholine is correlated with Candida tropicalisand promotes diarrhea and pathogen clearance. npj Biofilms and Microbiomes (2023) 9:62.
- Md. Abul Kalam Azad, Hongbing Wang, Hua Yang, Bie Tan, Shuyu Zhou,Guiping Guan.*Effects of dietary carboxymethyl pachyman on oxidative stress and inflammation in weaned piglets challenged with diquat. Anim Feed Sci Technol. 276 (2021) 114922.
- Guo Jieping, He Liuqin, Li Tiejun, Yin Jie, YinYulong*,Guan Guiping*.Antioxidant and Anti-Inflammatory Effects of Different Zinc Sources on Diquat-Induced Oxidant Stress in a Piglet Model. Biomed Res Int., 2020, 2020: 3464068.
- Guan, Guiping,Azad MAK, Lin Y, Kim SW, Tian Y, Liu G and Wang H (2019). Biological Effects and Applications of Chitosan and Chito-Oligosaccharides. Front. Physiol. 10:516.
- Guan, Guiping,Ding, S., Yin, Y., Duraipandiyan, V., Al-dhabi, N.A., and Liu, G. (2019). Macleaya cordata extract alleviated oxidative stress and altered innate immune response in mice challenged with enterotoxigenic Escherichia coli. Sci China Life Sci 62, 1019–1027.
- Guiping Guan,Shile Lan. Implications of Antioxidant Systems in Inflammatory Bowel Disease. BioMed Research International, 2018, 2018: 1290179.
- Roisbel Aroche, Yordan Mart´ ıne, zheng Ruan*,Guiping Guan*,Samuel Waititu, Charles M. Nyachoti, Dairon M´as, Shile Lan, Dietary Inclusion of a Mixed Powder of Medicinal Plant Leaves Enhances the Feed Efficiency and Immune Function in Broiler Chickens. Journal of Chemistry, 2018, 2018: 4073068.
- Chenxin Fu,Guiping Guan*, Hongbing Wang*. The Anticancer Effect of Sanguinarine: A Review [J]. Curr Pharm Des. 2018，24（24）：2760-2764.
- Liu G，Ren W，Fang J，Hu CA，Guan, Guiping，Al-Dhabi NA，Yin J，Duraipandiyan V，Chen S，Peng Y，Yin Y. L-Glutamine and L-arginine protect against enterotoxigenic Escherichia coli infection via intestinal innate immunity in mice[J]. Amino Acids. 2017，49（12）：1945-1954.
- Guiping Guan,Bie Tan, Kang Yao, Jun Fang, Guangzu He, Tiejun Li, Hussain Sun, YulongYin. Dynamic profiles of amino acids released from different nitrogen composited diets in the jejunum of pigs. J Anim Sci, 2016,94:283–285.
- Guiping Guan,Hongbing Wang, Shuai Chen, Gang Liu, Xia Xiong, Bie Tan, Veeramuthu Duraipandiyan, Naif Abdullah Al-Dhabi, and Jun Fang，Dietary Chitosan Supplementation Increases Microbial Diversity and Attenuates the Severity of Citrobacter rodentium Infection in Mice. Mediators of Inflammation. 2016, 2016 :9236196.
- Bie Tan#,Guiping Guan#, Kang Yao, Jun Fang, Yingying Liu, Tiejun Li, Hussain Sun,and YulongYin, Profiles of amino acids released from different nitrogen composited diets in different segments of the gastrointestinal tract of pigs. J. Anim. Sci, 2016, 94:272–275. (共同第一作者).
- Guiping Guan,Hongbing Wang, Hanhui Peng, and Guanya Li，Low Dosage of Chitosan Supplementation Improves Intestinal Permeability and Impairs Barrier Function in Mice. BioMed Research International. 2016, 2016 :4847296.
- Gang Liu#,Guiping Guan#, Jun Fang, Yordan Martínez, Shuai Chen, Peng Bin, Veeramuthu Duraipandiyan, Ting Gong, Myrlene Carine B. Tossou, Naif Abdullah Al-Dhabi, and Yulong Yin. Macleaya cordata Extract Decreased Diarrhea Score and Enhanced Intestinal Barrier Function in Growing Piglets. BioMed Research International, 2016, 2016:1069585. (共同第一作者).
- Liu G, Chen S,Guan, Guiping*，Tan J, Al-DhabiNA, Wang HB*, Duraipandiyan V, Fang J. Chitosan Modulates Inflammatory Responses in Rats Infected with Enterotoxigenic Escherichia coli. MEDIATORS OF INFLAMMATION, 2016, 2016: 7432845 (通讯作者).
- Guiping Guan,Bie Tan, Yingying Liu, Xiangfeng Kong, Qiling Chen, Guangzu He, Jun Fang, Jianjun Li, and Yulong Yin*. Apparent digestibility of crude protein, gross energy, gross ash and amino acids from four dietary protein sources in young pigs. Amino Acids , 2015, 47:1682.
- Guiping Guan,Gang Liu, Wenkai Ren, Xia Xiong, Bie Tan, Peng Bin, Shuai Chen, Wei Gao, Ruilin Huang, Yulong Yin, Protective effect of dietary L-arginine against enterotoxigenic Escherichia coli infection in mice. Amino Acids, 2015, 47:1683.
- Guiping Guan,Xiao Luo, Jinping Deng, Gang Liu2, Bie Tan, Hongbing Wang, Wei Gao, Fang Jun,Tiejun Li. Effect of dietary selenium yeast on the growth performance and serum amino acids level in early weaned. Amino Acids, 2015, 47:1643.
- 李光燃,谭碧娥*（通讯作者）,管桂萍,印遇龙.钠离子依赖性中性氨基酸转运载体2特性、表达调控及功能.动物营养学报，2015, 27(11): 3338-3344.
二、荣获省部级科技奖项
1.湖南省自然科学奖二等奖“壳寡（聚）糖对动物营养生理的调控作用及其机理研究” （2018）
2.湖南省科技进步二等奖“安全质优生猪养殖全程益生菌营养调控关键技术创新与应用”（2015）
3.北京市科学技术三等奖“食用菌品种多相鉴定鉴别技术体系”（2011）
三、研究项目（近5年）：
1.湖南省重点研发计划项目，工厂化食用菌数智化生产关键技术研究及示范，2025-2027，主持
2.国家自然基金面上项目，植物乳杆菌通过RIP3信号通路调控仔猪肠道巨噬细胞程序性坏死的机制研究，2025-2028，第二参与
3.湖南省教育厅科学研究重点项目，血根碱调控ETEC群体感应缓解断奶仔猪腹泻的作用机制，2023-2026，主持
4.湖南省自然科学基金面上项目，基于肠上皮细胞模型探究博落回生物碱干预ETEC介导的仔猪细菌性腹泻作用机制，2021-2023，主持
5.湖南省中医药科研计划重点项目，艾叶配伍苍术高效烟熏空气消毒剂的研制，2022-2024，主持
6.国家留学基金委公派访问学者资助项目，2018-2019，主持
7.长沙市科技局自然科学基金项目，博落回生物碱缓解ETEC介导的猪肠上皮细胞应激损伤作用机制，2021-2023，主持
8.湖南省教育厅科研重点项目，茯苓多糖调控仔猪肠道微生物作用于养殖臭气减排研究，2019-2021主持
9.国家自然科学基金青年项目，德氏乳杆菌通过调控细胞自噬缓解仔猪肠道炎症的机制研究，2020-2022，第二参与
10.国家自然科学基金青年项目，茯苓多糖通过NF-κB信号通路调控仔猪肠道氧化损伤修复的机制，2015-2017，主持
11.国家自然科学基金面上项目，ETEC腹泻仔猪Th17和Treg细胞分化及JAK-STAT途径的作用机制，2016-2017，参与
12.中国科学院亚热带农业生态过程重点实验室开放基金项目，茯苓多糖对氧化损伤猪肠上皮细胞能量代谢与蛋白质代谢的调控研究，2015-2017，主持 |
