姓 名 |
夏石头 |
性 别 |
男 |
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职 称 |
教授 |
最高学历∕学位 |
博士 | |||
博导/硕导 |
植物学专业博士生导师(领衔人)、硕士生导师 | |||||
研究领域与研究方向: 研究领域为植物生理与分子生物学,主要以模式植物拟南芥和水稻为材料,研究植物抗性的分子机理,特别是植物先天免疫的分子机理与植物激素水杨酸调控植物抗性的分子机制。通过突变体筛选、基因图位克隆、基因表达调控、蛋白蛋白相互作用等现代遗传学、植物生理学、分子生物学的新技术等,深入探究植物抗生物、非生物逆境中新的调控元素,解析植物抗逆机理及其信号途径,探索利用环境友好策略调控植物生长发育,控制植物病害、利用植物先天免疫来抵御微生物侵染的新途径。 | ||||||
一、个人所获荣誉 荣获湖南省第二届优秀科技工作者,获得湖南省科技进步奖一等奖1项,湖南省第十二届自然科学优秀论文一等奖、二等奖各2项,湖南农业大学自然科学奖三等奖1项;湖南省教学成果奖一等奖2项、三等奖2项,高等农业教育优秀论文二等奖,湖南农业大学教学成果奖一等奖和二等奖各2项;获省农作物品种审定委员会审定水稻新品种2个,国家发明专利4项。 | ||||||
二、学习与工作经历(含出国访问、进修及社会兼职等) 学习经历: 1993年湖南学院园艺教育本科、学士学位; 2000年湖南农业大学植物学硕士、硕士学位; 2007年湖南农业大学、加拿大英属哥伦比亚大学(UBC)联合培养植物学博士、博士学位。 工作经历: 1993.06-至今,湖南农业大学植物学专业教学科研; 2004.02-2005.02,加拿大英属哥伦比亚大学(UBC)国家公派访问学者、联合培养博士; 2005-2008,北京生命科学研究所NIBS高级访问学者、博士后; 2011.6-2012.6,加拿大英属哥伦比亚大学(UBC)国家公派访问学者; 2014.10-2015.2,英国格林威治大学(UG)访问教授; 2011年-至今,中国植物生理与植物分子生物学学会会员; 2018年-至今,湖南省植物生理与分子生物学常务理事; 2011年-至今,国家自然科学基金通讯评审专家、教育部科技项目评审专家、国家留学基金委公派项目评审专家; 2021年-至今,植物学报责任编委。 | ||||||
三、主讲课程 国家级一流本科课程、国家精品在线开放课程“植物生理学”; 国家精品视频精品课程“植物生理与人类生活”; “植物生理学”“生物分析技术”和“生物统计学”双语课程; 硕士研究生“植物逆境与信号转导”; 博士研究生“系统生物学”、博士生“现代植物学专题”。 |
三、科研成果 1. Jiameng Lan, Siyu Chen, Joana Pico, Kevin Ao,Shitou Xia, Shucai Wang, Xin Li, Simone D. Castellarin, Yuelin Zhang. Epigenetic regulation of N-hydroxypipecolic acid biosynthesis by the AIPP3-PHD2-CPL2 complex.Journal of Integrative Plant Biology, 2023, ORCID iD: 0000-0002-2187-3199 2. Tang, X.; Zhong,W.; Wang, K.; Gong, X.; Xia, Y.; Nong, J.; Xiao, L.*; Xia, S*. Regulation of Grain Chalkiness and Starch Metabolism by FLO2 Interaction Factor 3, a bHLH Transcription Factor inOryza sativa.Int. J. Mol. Sci. 2023, 24, 12778. 3. Qin, L.; Nong, J.; Cui, K.;Tang, X.; Gong, X.; Xia, Y.; Xu, Y.; Qiu, Y.; Li, X.*;Xia, S*. SsCak1 regulates growth and pathogenicity inSclerotinia sclerotiorum.Int. J. Mol. Sci. 2023, 24, 12610. 4. 吴楠,覃磊,崔看,李海鸥,刘忠松,夏石头*.甘蓝型油菜EXA1的克隆及其对植物抗病的调控作用.植物学报, 2023, 58 (3): 385–393 5. Chenghuizi Yang, Lan Tang, Lei Qin, Weiping Zhong, Xianyu Tang, Xin Gong, Wenqi Xie, Yifu Li,Shitou Xia*. mRNA turnover protein 4 is vital for fungal pathogenicity and response to oxidative stress inSclerotinia sclerotiorum.Pathogens, 2023, 12, 281. 6. Xiaobo Zhang, Lei Qin, Junxing Lu, Yunong Xia, Xianyu Tang, Xun Lu,Shitou Xia*. Genome-wide identification of GYF-domain encoding genes in threeBrassica species and their expression responding toSclerotinia sclerotiorum inBrassica napus.Genes, 2023, 14, 224. 7. 吴楠,覃磊,彭志红,夏石头*.系统获得性抗性移动信号Pip/NHP研究进展(特邀综述).植物学报, 2022, 57 (4): 412-421. 8. 覃磊,彭志红,夏石头*.植物NLR免疫受体的识别、免疫激活与信号调控(特邀综述).植物学报, 2022, 57 (1): 12-23. 9. Li, W.; Lu, J.; Yang, C.; Arildsen, K.; Li, X.;Xia, S*. An Amidase Contributes to Full Virulence ofSclerotinia sclerotiorum.Int. J. Mol. Sci. 2022, 23, 11207. 10. Wei Li, Junxing Lu, Chenghuizi Yang,Shitou Xia*. Identification of receptor-like proteins induced by Sclerotinia sclerotiorum inBrassica napus.Frontiers in Plant Science, 2022, 13:944763. 11. Cui, K.; Qin, L.; Tang, X.; Nong, J.; Chen, J.; Wu, N.; Gong, X.; Yi, L.; Yang, C.;Xia, S*. A single amino acid substitution in RFC4 leads to endoduplication and compromised resistance to DNA damage inArabidopsis thaliana.Genes, 2022, 13, 1037. 12. Xingchuan Huang, Yanan Liu, Jianhua Huang, W. G. Dilantha Fernando, Xin Li,Shitou Xia*. Activation of NLR-mediated autoimmunity in Arabidopsis early in short days 4 mutant.Frontiers in Plant Science, 2022, 13:881212. 13. Chenghuizi Yang, Wei Li, Xingchuan Huang, Xianyu Tang, Lei Qin, Yanan Liu, Yunong Xia, Zhihong Peng,Shitou Xia*. SsNEP2 contributes to the virulence ofSclerotinia sclerotiorum.Pathogens, 2022, 11, 446. 14. Yan Xu, Kevin Ao, Lei Tian, Yilan Qiu, Xingchuan Huang, Xueru Liu, Ryan Hoy, Yishan Zhang, Khalid Youssef Rashid,Shitou Xia, Xin Li. A forward genetic screen inSclerotinia sclerotiorum revealed the transcriptional regulation of its sclerotial melanization pathway.MPMI, 2022, 35(3):244–256. 15. Shitou Xia*, Xueru Liu, Yuelin Zhang*. Calcium channels at the center of nucleotide-binding leucine-rich repeat receptor-mediated plant immunity.Journal of Genetics and Genomics, 2021, 48:429-432. 16. Jin Chen, Feiying Zhu, Ling Liu, Lixiong Yi, Yanjiao Dai, Shan Chen, Aiguo He,Shitou Xia*. Integrative analyses of transcriptome and metabolome shed light on the regulation of secondary metabolites in pseudobulbs of twoBletilla striata (Thunb.) Reichb.f. varieties.Journal of Applied Research on Medicinal and Aromatic Plants, 2021, 20:100280. 17. 杨程惠子,唐先宇,李威,夏石头*. NLR及其在植物抗病中的调控作用.植物学报, 2020, 55 (4): 497–504. 18. Shitou Xia*, Yan Xu, Ryan Hoy, Julia Zhang, Lei Qin, Xin Li*. The notorious soilborne pathogenic fungusSclerotinia sclerotiorum: An update on genes studied with mutant analysis.Pathogens, 2020, 9, 27. 19. Tongjun Sun, Jianhua Huang, Yan Xu, Vani Verma, Beibei Jing, Yulin Sun, Alberto Ruiz Orduna, Hainan Tian, Xingchuan Huang,Shitou Xia, Laurel Schafer, Reinhard Jetter, Yuelin Zhang, Xin Li. Redundant CAMTA transcription factors negatively regulate the biosynthesis of salicylic acid and N-Hydroxypipecolic acid by modulating the expression of SARD1 and CBP60g.Molecular Plant, 2020, 13:144–156. 20. Wu Z, Li M, Dong OX,Xia S, Liang W, Bao Y, Wasteneys G, Li X. Differential regulation of TNL-mediated immune signaling by redundant helper CNLs.New Phytologist, 2019, doi: 10.1111/nph.15665. 21. Dong OX, Ao K, Xu F, Johnson KCM, Wu Y, Li L,Xia S, Liu Y, Huang Y, Rodriguez E, Chen X, Chen S, Zhang Y, Petersen M, Li X. Individual components of paired typical NLR immune receptors are regulated by distinct E3 ligases.Nature Plants, 2018,4(9):699-710. 22. Li Tang, Bigang Mao, Yaokui Li, Qiming Lv, LiPing Zhang, Caiyan Chen, Hanjie He, Weiping Wang, Xiongfeng Zeng, Ye Shao, Yinlin Pan, Yuanyi Hu, Yan Peng, Xiqin Fu, Hongqing Li,Shitou Xia*, Bingran Zhao*. Knockout of OsNramp5 using the CRISPR/Cas9 system produces low Cd-accumulating indica rice without compromising yield.Scientific Reports, 2017, 7: 14438. 23. Zhongshou Wu, Shuai Huang, Xiaobo Zhang, Di Wu,Shitou Xia*, Xin Li*. Regulation of plant immune receptor accumulation through translational repression by a glycine-tyrosine-phenylalanine (GYF) domain protein.eLife, 2017, 6: e23684. 24. Kaeli C.M. Johnson†,Shitou Xia†, Xiaoqi Feng, Xin Li. The Chromatin Remodeler SPLAYED Negatively Regulates SNC1-Mediated Immunity.Plant Cell Physiol. 2015, 56(8): 1616–1623. 25. Xia S, Cheng YT, Huang S, Win J, Soards A, Jinn TL, Jones JD, Kamoun S, Chen S, Zhang Y, Li X. Regulation of transcription of nucleotide-binding leucine-rich repeat-encoding genes SNC1 and RPP4 via H3K4 trimethylation.Plant Physiology, 2013, 162(3):1694-705. 26. Xia S*, Xiao L, Gannon P, Li X. RFC3 regulates cell proliferation and pathogen resistance in Arabidopsis.Plant Signal & Behavior, 2010, 5(2): 168-170. 27. Qu Na, Gan Wenjian, Bi Donglin,Xia Shitou, Li Xin, Zhang Yuelin. Two BTB protein function redundantly as negative regulators of defense against pathogens in Arabidopsis.Botany, 2010, 88: 953-960. 28. Xia Shitou, Zhu Zhaohai, Hao Lin, Chen Jin-Gui, Xiao Langtao, Zhang Yuelin, Li Xin. Negative Regulation of Systemic Acquired Resistance by Replication Factor C Subunit 3 in Arabidopsis.Plant Physiology, 2009, 150:2009-2017. |
四、研究项目
1.国家自然科学基金联合基金重点支持项目:甘蓝型油菜黄籽性状遗传稳定性的调控机制研究,参与; 2.国家自然科学基金面上项目:油菜GYF1与互作因子对真菌病害抗性的调控机理研究(31971836),主持; 3.湖南省自然科学杰出青年基金项目:复制因子C各亚基生物学功能研究及在超级稻亲本改良中的应用(11JJ1007),主持; 4.国家自然科学基金面上项目:复制因子C亚基3对拟南芥生长发育的调控机理研究(30970247),主持; 5.湖南省高等学校科学研究重点项目:GYL1与SNC1的互作及其对植物免疫的调控作用研 究(17A095),主持; 6.湖南省重点研发计划项目:油菜高产油新品种选育和机械化制种技术研究(2016NK2121),参与; 7.湖南省研究生教学平台项目:植物逆境与信号转导(2020jxpt002),主持。 8.湖南省教改项目:基于一流专业建设的高等农业院校多学科交叉融合生物科学人才培养模式的创新实践(HNJG-2021-0486),主持。
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五、联系方式(E-mail or QQ)
E-mail : xstone0505@163.com |
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